WEB-based GEne SeT AnaLysis Toolkit
 
Translating gene lists into biological insights...
 


User data and parameters: User data: textAreaUpload.txt, Organism: hsapiens, Id Type: ensembl_gene_stable_id, Ref Set: entrezgene, Significance Level: Top10, Statistics Test: Hypergeometric, MTC: BH, Minimum: 2

The results for each enriched gene sets are listed in this table.
For each gene set, the first row lists database name, gene set name , and corresponding gene set ID.
The second row lists the following statistics:
Finally, genes in the pathway are listed. For each gene, the table lists the user uploaded ID and value (optional), Entrez ID, Ensembl Gene Stable ID, Gene symbol, and description. Ensembl Gene Stable ID and Entrez Gene ID are linked to the Ensembl and Entrez Gene databases, respectively.

Database:KEGG pathway       Name:Ubiquitin mediated proteolysis       ID:04120
C=135; O=39; E=5.74; R=6.79; rawP=5.65e-22; adjP=8.98e-20
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000072803 NA FBXW11 F-box and WD repeat domain containing 11 23291 ENSG00000072803
2  ENSG00000175104 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
3  ENSG00000153827 NA TRIP12 thyroid hormone receptor interactor 12 9320 ENSG00000153827
4  ENSG00000115760 NA BIRC6 baculoviral IAP repeat containing 6 57448 ENSG00000115760
5  ENSG00000003096 NA KLHL13 kelch-like 13 (Drosophila) 90293 ENSG00000003096
6  ENSG00000104343 NA UBE2W ubiquitin-conjugating enzyme E2W (putative) 55284 ENSG00000104343
7  ENSG00000144744 NA UBA3 ubiquitin-like modifier activating enzyme 3 9039 ENSG00000144744
8  ENSG00000101966 NA XIAP X-linked inhibitor of apoptosis 331 ENSG00000101966
9  ENSG00000116661 NA FBXO2 F-box protein 2 26232 ENSG00000116661
10  ENSG00000163743 NA RCHY1 ring finger and CHY zinc finger domain containing 1, E3 ubiquitin protein ligase 25898 ENSG00000163743
11  ENSG00000110344 NA UBE4A ubiquitination factor E4A 9354 ENSG00000110344
12  ENSG00000104517 NA UBR5 ubiquitin protein ligase E3 component n-recognin 5 51366 ENSG00000104517
13  ENSG00000110330 NA BIRC2 baculoviral IAP repeat containing 2 329 ENSG00000110330
14  ENSG00000069869 NA NEDD4 neural precursor cell expressed, developmentally down-regulated 4, E3 ubiquitin protein ligase 4734 ENSG00000069869
15  ENSG00000138641 NA HERC3 HECT and RLD domain containing E3 ubiquitin protein ligase 3 8916 ENSG00000138641
16  ENSG00000153107 NA ANAPC1 anaphase promoting complex subunit 1 64682 ENSG00000153107
17  ENSG00000033800 NA PIAS1 protein inhibitor of activated STAT, 1 8554 ENSG00000033800
18  ENSG00000166266 NA CUL5 cullin 5 8065 ENSG00000166266
19  ENSG00000114062 NA UBE3A ubiquitin protein ligase E3A 7337 ENSG00000114062
20  ENSG00000135679 NA MDM2 Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) 4193 ENSG00000135679
21  ENSG00000132388 NA UBE2G1 ubiquitin-conjugating enzyme E2G 1 7326 ENSG00000132388
22  ENSG00000196510 NA ANAPC7 anaphase promoting complex subunit 7 51434 ENSG00000196510
23  ENSG00000123124 NA WWP1 WW domain containing E3 ubiquitin protein ligase 1 11059 ENSG00000123124
24  ENSG00000009335 NA UBE3C ubiquitin protein ligase E3C 9690 ENSG00000009335
25  ENSG00000134574 NA DDB2 damage-specific DNA binding protein 2, 48kDa 1643 ENSG00000134574
26  ENSG00000198642 NA KLHL9 kelch-like 9 (Drosophila) 55958 ENSG00000198642
27  ENSG00000134086 NA VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 7428 ENSG00000134086
28  ENSG00000078747 NA ITCH itchy E3 ubiquitin protein ligase 83737 ENSG00000078747
29  ENSG00000077721 NA UBE2A ubiquitin-conjugating enzyme E2A 7319 ENSG00000077721
30  ENSG00000036257 NA CUL3 cullin 3 8452 ENSG00000036257
31  ENSG00000012048 NA BRCA1 breast cancer 1, early onset 672 ENSG00000012048
32  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
33  ENSG00000108395 NA TRIM37 tripartite motif containing 37 4591 ENSG00000108395
34  ENSG00000033178 NA UBA6 ubiquitin-like modifier activating enzyme 6 55236 ENSG00000033178
35  ENSG00000131788 NA PIAS3 protein inhibitor of activated STAT, 3 10401 ENSG00000131788
36  ENSG00000004897 NA CDC27 cell division cycle 27 homolog (S. cerevisiae) 996 ENSG00000004897
37  ENSG00000103657 NA HERC1 HECT and RLD domain containing E3 ubiquitin protein ligase family member 1 8925 ENSG00000103657
38  ENSG00000108094 NA CUL2 cullin 2 8453 ENSG00000108094
39  ENSG00000140464 NA PML promyelocytic leukemia 5371 ENSG00000140464


Database:KEGG pathway       Name:MAPK signaling pathway       ID:04010
C=268; O=40; E=11.40; R=3.51; rawP=5.69e-12; adjP=4.52e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000158711 NA ELK4 ELK4, ETS-domain protein (SRF accessory protein 1) 2005 ENSG00000158711
2  ENSG00000107643 NA MAPK8 mitogen-activated protein kinase 8 5599 ENSG00000107643
3  ENSG00000175104 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
4  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
5  ENSG00000196712 NA NF1 neurofibromin 1 4763 ENSG00000196712
6  ENSG00000109270 NA LAMTOR3 late endosomal/lysosomal adaptor, MAPK and MTOR activator 3 8649 ENSG00000109270
7  ENSG00000087095 NA NLK nemo-like kinase 51701 ENSG00000087095
8  ENSG00000213341 NA CHUK conserved helix-loop-helix ubiquitous kinase 1147 ENSG00000213341
9  ENSG00000107758 NA PPP3CB protein phosphatase 3, catalytic subunit, beta isozyme 5532 ENSG00000107758
10  ENSG00000169967 NA MAP3K2 mitogen-activated protein kinase kinase kinase 2 10746 ENSG00000169967
11  ENSG00000099942 NA CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1399 ENSG00000099942
12  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365
13  ENSG00000050748 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748
14  ENSG00000180370 NA PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 5062 ENSG00000180370
15  ENSG00000100614 NA PPM1A protein phosphatase, Mg2+/Mn2+ dependent, 1A 5494 ENSG00000100614
16  ENSG00000185386 NA MAPK11 mitogen-activated protein kinase 11 5600 ENSG00000185386
17  ENSG00000101224 NA CDC25B cell division cycle 25 homolog B (S. pombe) 994 ENSG00000101224
18  ENSG00000166484 NA MAPK7 mitogen-activated protein kinase 7 5598 ENSG00000166484
19  ENSG00000139625 NA MAP3K12 mitogen-activated protein kinase kinase kinase 12 7786 ENSG00000139625
20  ENSG00000142875 NA PRKACB protein kinase, cAMP-dependent, catalytic, beta 5567 ENSG00000142875
21  ENSG00000113721 NA PDGFRB platelet-derived growth factor receptor, beta polypeptide 5159 ENSG00000113721
22  ENSG00000135090 NA TAOK3 TAO kinase 3 51347 ENSG00000135090
23  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
24  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
25  ENSG00000109756 NA RAPGEF2 Rap guanine nucleotide exchange factor (GEF) 2 9693 ENSG00000109756
26  ENSG00000071054 NA MAP4K4 mitogen-activated protein kinase kinase kinase kinase 4 9448 ENSG00000071054
27  ENSG00000160551 NA TAOK1 TAO kinase 1 57551 ENSG00000160551
28  ENSG00000011566 NA MAP4K3 mitogen-activated protein kinase kinase kinase kinase 3 8491 ENSG00000011566
29  ENSG00000145715 NA RASA1 RAS p21 protein activator (GTPase activating protein) 1 5921 ENSG00000145715
30  ENSG00000073009 NA IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 8517 ENSG00000073009
31  ENSG00000067191 NA CACNB1 calcium channel, voltage-dependent, beta 1 subunit 782 ENSG00000067191
32  ENSG00000167193 NA CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 1398 ENSG00000167193
33  ENSG00000055208 NA TAB2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 23118 ENSG00000055208
34  ENSG00000111266 NA DUSP16 dual specificity phosphatase 16 80824 ENSG00000111266
35  ENSG00000100968 NA NFATC4 nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 4776 ENSG00000100968
36  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
37  ENSG00000091436 NA ZAK sterile alpha motif and leucine zipper containing kinase AZK 51776 ENSG00000091436
38  ENSG00000065559 NA MAP2K4 mitogen-activated protein kinase kinase 4 6416 ENSG00000065559
39  ENSG00000177189 NA RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6197 ENSG00000177189
40  ENSG00000153956 NA CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 781 ENSG00000153956


Database:KEGG pathway       Name:Pathways in cancer       ID:05200
C=326; O=44; E=13.87; R=3.17; rawP=1.63e-11; adjP=8.64e-10
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107643 NA MAPK8 mitogen-activated protein kinase 8 5599 ENSG00000107643
2  ENSG00000175104 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
3  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
4  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230
5  ENSG00000101966 NA XIAP X-linked inhibitor of apoptosis 331 ENSG00000101966
6  ENSG00000213341 NA CHUK conserved helix-loop-helix ubiquitous kinase 1147 ENSG00000213341
7  ENSG00000134982 NA APC adenomatous polyposis coli 324 ENSG00000134982
8  ENSG00000110330 NA BIRC2 baculoviral IAP repeat containing 2 329 ENSG00000110330
9  ENSG00000099942 NA CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1399 ENSG00000099942
10  ENSG00000033800 NA PIAS1 protein inhibitor of activated STAT, 1 8554 ENSG00000033800
11  ENSG00000139687 NA RB1 retinoblastoma 1 5925 ENSG00000139687
12  ENSG00000135679 NA MDM2 Mdm2, p53 E3 ubiquitin protein ligase homolog (mouse) 4193 ENSG00000135679
13  ENSG00000140443 NA IGF1R insulin-like growth factor 1 receptor 3480 ENSG00000140443
14  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365
15  ENSG00000050748 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748
16  ENSG00000128602 NA SMO smoothened, frizzled family receptor 6608 ENSG00000128602
17  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
18  ENSG00000105976 NA MET met proto-oncogene (hepatocyte growth factor receptor) 4233 ENSG00000105976
19  ENSG00000113721 NA PDGFRB platelet-derived growth factor receptor, beta polypeptide 5159 ENSG00000113721
20  ENSG00000004975 NA DVL2 dishevelled, dsh homolog 2 (Drosophila) 1856 ENSG00000004975
21  ENSG00000077092 NA RARB retinoic acid receptor, beta 5915 ENSG00000077092
22  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
23  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
24  ENSG00000134086 NA VHL von Hippel-Lindau tumor suppressor, E3 ubiquitin protein ligase 7428 ENSG00000134086
25  ENSG00000196569 NA LAMA2 laminin, alpha 2 3908 ENSG00000196569
26  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
27  ENSG00000157500 NA APPL1 adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1 26060 ENSG00000157500
28  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
29  ENSG00000148737 NA TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 6934 ENSG00000148737
30  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
31  ENSG00000131788 NA PIAS3 protein inhibitor of activated STAT, 3 10401 ENSG00000131788
32  ENSG00000047410 NA TPR translocated promoter region, nuclear basket protein 7175 ENSG00000047410
33  ENSG00000073009 NA IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 8517 ENSG00000073009
34  ENSG00000107882 NA SUFU suppressor of fused homolog (Drosophila) 51684 ENSG00000107882
35  ENSG00000167193 NA CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 1398 ENSG00000167193
36  ENSG00000111186 NA WNT5B wingless-type MMTV integration site family, member 5B 81029 ENSG00000111186
37  ENSG00000108094 NA CUL2 cullin 2 8453 ENSG00000108094
38  ENSG00000140464 NA PML promyelocytic leukemia 5371 ENSG00000140464
39  ENSG00000113318 NA MSH3 mutS homolog 3 (E. coli) 4437 ENSG00000113318
40  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
41  ENSG00000169083 NA AR androgen receptor 367 ENSG00000169083
42  ENSG00000138448 NA ITGAV integrin, alpha V 3685 ENSG00000138448
43  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
44  ENSG00000196591 NA HDAC2 histone deacetylase 2 3066 ENSG00000196591


Database:KEGG pathway       Name:ErbB signaling pathway       ID:04012
C=87; O=20; E=3.70; R=5.40; rawP=5.28e-10; adjP=2.10e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107643 NA MAPK8 mitogen-activated protein kinase 8 5599 ENSG00000107643
2  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
3  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
4  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
5  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
6  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
7  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
8  ENSG00000143322 NA ABL2 v-abl Abelson murine leukemia viral oncogene homolog 2 27 ENSG00000143322
9  ENSG00000099942 NA CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1399 ENSG00000099942
10  ENSG00000145349 NA CAMK2D calcium/calmodulin-dependent protein kinase II delta 817 ENSG00000145349
11  ENSG00000167193 NA CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 1398 ENSG00000167193
12  ENSG00000050748 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748
13  ENSG00000180370 NA PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 5062 ENSG00000180370
14  ENSG00000071051 NA NCK2 NCK adaptor protein 2 8440 ENSG00000071051
15  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
16  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
17  ENSG00000108443 NA RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 6198 ENSG00000108443
18  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
19  ENSG00000109458 NA GAB1 GRB2-associated binding protein 1 2549 ENSG00000109458
20  ENSG00000065559 NA MAP2K4 mitogen-activated protein kinase kinase 4 6416 ENSG00000065559


Database:KEGG pathway       Name:RNA transport       ID:03013
C=151; O=26; E=6.42; R=4.05; rawP=1.26e-09; adjP=4.01e-08
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000058804 NA TMEM48 transmembrane protein 48 55706 ENSG00000058804
2  ENSG00000063046 NA EIF4B eukaryotic translation initiation factor 4B 1975 ENSG00000063046
3  ENSG00000173674 NA EIF1AX eukaryotic translation initiation factor 1A, X-linked 1964 ENSG00000173674
4  ENSG00000170473 NA WIBG within bgcn homolog (Drosophila) 84305 ENSG00000170473
5  ENSG00000075151 NA EIF4G3 eukaryotic translation initiation factor 4 gamma, 3 8672 ENSG00000075151
6  ENSG00000113569 NA NUP155 nucleoporin 155kDa 9631 ENSG00000113569
7  ENSG00000110321 NA EIF4G2 eukaryotic translation initiation factor 4 gamma, 2 1982 ENSG00000110321
8  ENSG00000030066 NA NUP160 nucleoporin 160kDa 23279 ENSG00000030066
9  ENSG00000110713 NA NUP98 nucleoporin 98kDa 4928 ENSG00000110713
10  ENSG00000172239 NA PAIP1 poly(A) binding protein interacting protein 1 10605 ENSG00000172239
11  ENSG00000155561 NA NUP205 nucleoporin 205kDa 23165 ENSG00000155561
12  ENSG00000107581 NA EIF3A eukaryotic translation initiation factor 3, subunit A 8661 ENSG00000107581
13  ENSG00000163904 NA SENP2 SUMO1/sentrin/SMT3 specific peptidase 2 59343 ENSG00000163904
14  ENSG00000082516 NA GEMIN5 gem (nuclear organelle) associated protein 5 25929 ENSG00000082516
15  ENSG00000047410 NA TPR translocated promoter region, nuclear basket protein 7175 ENSG00000047410
16  ENSG00000153201 NA RANBP2 RAN binding protein 2 5903 ENSG00000153201
17  ENSG00000082898 NA XPO1 exportin 1 (CRM1 homolog, yeast) 7514 ENSG00000082898
18  ENSG00000136937 NA NCBP1 nuclear cap binding protein subunit 1, 80kDa 4686 ENSG00000136937
19  ENSG00000069248 NA NUP133 nucleoporin 133kDa 55746 ENSG00000069248
20  ENSG00000125676 NA THOC2 THO complex 2 57187 ENSG00000125676
21  ENSG00000134001 NA EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1965 ENSG00000134001
22  ENSG00000151461 NA UPF2 UPF2 regulator of nonsense transcripts homolog (yeast) 26019 ENSG00000151461
23  ENSG00000124789 NA NUP153 nucleoporin 153kDa 9972 ENSG00000124789
24  ENSG00000100664 NA EIF5 eukaryotic translation initiation factor 5 1983 ENSG00000100664
25  ENSG00000169251 NA NMD3 NMD3 homolog (S. cerevisiae) 51068 ENSG00000169251
26  ENSG00000139496 NA NUPL1 nucleoporin like 1 9818 ENSG00000139496


Database:KEGG pathway       Name:Focal adhesion       ID:04510
C=200; O=29; E=8.51; R=3.41; rawP=8.70e-09; adjP=2.31e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107643 NA MAPK8 mitogen-activated protein kinase 8 5599 ENSG00000107643
2  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
3  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
4  ENSG00000058272 NA PPP1R12A protein phosphatase 1, regulatory subunit 12A 4659 ENSG00000058272
5  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
6  ENSG00000100852 NA ARHGAP5 Rho GTPase activating protein 5 394 ENSG00000100852
7  ENSG00000101966 NA XIAP X-linked inhibitor of apoptosis 331 ENSG00000101966
8  ENSG00000111245 NA MYL2 myosin, light chain 2, regulatory, cardiac, slow 4633 ENSG00000111245
9  ENSG00000196569 NA LAMA2 laminin, alpha 2 3908 ENSG00000196569
10  ENSG00000182533 NA CAV3 caveolin 3 859 ENSG00000182533
11  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
12  ENSG00000110330 NA BIRC2 baculoviral IAP repeat containing 2 329 ENSG00000110330
13  ENSG00000099942 NA CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1399 ENSG00000099942
14  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
15  ENSG00000167193 NA CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 1398 ENSG00000167193
16  ENSG00000140443 NA IGF1R insulin-like growth factor 1 receptor 3480 ENSG00000140443
17  ENSG00000050748 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748
18  ENSG00000180370 NA PAK2 p21 protein (Cdc42/Rac)-activated kinase 2 5062 ENSG00000180370
19  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
20  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
21  ENSG00000067900 NA ROCK1 Rho-associated, coiled-coil containing protein kinase 1 6093 ENSG00000067900
22  ENSG00000138448 NA ITGAV integrin, alpha V 3685 ENSG00000138448
23  ENSG00000105976 NA MET met proto-oncogene (hepatocyte growth factor receptor) 4233 ENSG00000105976
24  ENSG00000144668 NA ITGA9 integrin, alpha 9 3680 ENSG00000144668
25  ENSG00000143127 NA ITGA10 integrin, alpha 10 8515 ENSG00000143127
26  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
27  ENSG00000134318 NA ROCK2 Rho-associated, coiled-coil containing protein kinase 2 9475 ENSG00000134318
28  ENSG00000215375 NA MYL5 myosin, light chain 5, regulatory 4636 ENSG00000215375
29  ENSG00000113721 NA PDGFRB platelet-derived growth factor receptor, beta polypeptide 5159 ENSG00000113721


Database:KEGG pathway       Name:Arrhythmogenic right ventricular cardiomyopathy (ARVC)       ID:05412
C=74; O=17; E=3.15; R=5.40; rawP=1.04e-08; adjP=2.35e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000198947 NA DMD dystrophin 1756 ENSG00000198947
2  ENSG00000183230 NA CTNNA3 catenin (cadherin-associated protein), alpha 3 29119 ENSG00000183230
3  ENSG00000170624 NA SGCD sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) 6444 ENSG00000170624
4  ENSG00000198626 NA RYR2 ryanodine receptor 2 (cardiac) 6262 ENSG00000198626
5  ENSG00000057294 NA PKP2 plakophilin 2 5318 ENSG00000057294
6  ENSG00000196569 NA LAMA2 laminin, alpha 2 3908 ENSG00000196569
7  ENSG00000183023 NA SLC8A1 solute carrier family 8 (sodium/calcium exchanger), member 1 6546 ENSG00000183023
8  ENSG00000148737 NA TCF7L2 transcription factor 7-like 2 (T-cell specific, HMG-box) 6934 ENSG00000148737
9  ENSG00000160789 NA LMNA lamin A/C 4000 ENSG00000160789
10  ENSG00000067191 NA CACNB1 calcium channel, voltage-dependent, beta 1 subunit 782 ENSG00000067191
11  ENSG00000134755 NA DSC2 desmocollin 2 1824 ENSG00000134755
12  ENSG00000046604 NA DSG2 desmoglein 2 1829 ENSG00000046604
13  ENSG00000138448 NA ITGAV integrin, alpha V 3685 ENSG00000138448
14  ENSG00000143127 NA ITGA10 integrin, alpha 10 8515 ENSG00000143127
15  ENSG00000144668 NA ITGA9 integrin, alpha 9 3680 ENSG00000144668
16  ENSG00000170558 NA CDH2 cadherin 2, type 1, N-cadherin (neuronal) 1000 ENSG00000170558
17  ENSG00000153956 NA CACNA2D1 calcium channel, voltage-dependent, alpha 2/delta subunit 1 781 ENSG00000153956


Database:KEGG pathway       Name:Hepatitis C       ID:05160
C=134; O=23; E=5.70; R=4.03; rawP=1.18e-08; adjP=2.35e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107643 NA MAPK8 mitogen-activated protein kinase 8 5599 ENSG00000107643
2  ENSG00000175104 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
3  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
4  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
5  ENSG00000106404 NA CLDN15 claudin 15 24146 ENSG00000106404
6  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
7  ENSG00000186951 NA PPARA peroxisome proliferator-activated receptor alpha 5465 ENSG00000186951
8  ENSG00000221914 NA PPP2R2A protein phosphatase 2, regulatory subunit B, alpha 5520 ENSG00000221914
9  ENSG00000213341 NA CHUK conserved helix-loop-helix ubiquitous kinase 1147 ENSG00000213341
10  ENSG00000126456 NA IRF3 interferon regulatory factor 3 3661 ENSG00000126456
11  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
12  ENSG00000131788 NA PIAS3 protein inhibitor of activated STAT, 3 10401 ENSG00000131788
13  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
14  ENSG00000073009 NA IKBKG inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase gamma 8517 ENSG00000073009
15  ENSG00000033800 NA PIAS1 protein inhibitor of activated STAT, 1 8554 ENSG00000033800
16  ENSG00000055332 NA EIF2AK2 eukaryotic translation initiation factor 2-alpha kinase 2 5610 ENSG00000055332
17  ENSG00000050748 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748
18  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365
19  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
20  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
21  ENSG00000134001 NA EIF2S1 eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa 1965 ENSG00000134001
22  ENSG00000185386 NA MAPK11 mitogen-activated protein kinase 11 5600 ENSG00000185386
23  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030


Database:KEGG pathway       Name:Neurotrophin signaling pathway       ID:04722
C=127; O=22; E=5.40; R=4.07; rawP=2.05e-08; adjP=3.34e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000107643 NA MAPK8 mitogen-activated protein kinase 8 5599 ENSG00000107643
2  ENSG00000175104 NA TRAF6 TNF receptor-associated factor 6, E3 ubiquitin protein ligase 7189 ENSG00000175104
3  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
4  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
5  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
6  ENSG00000111348 NA ARHGDIB Rho GDP dissociation inhibitor (GDI) beta 397 ENSG00000111348
7  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
8  ENSG00000099942 NA CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1399 ENSG00000099942
9  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
10  ENSG00000145349 NA CAMK2D calcium/calmodulin-dependent protein kinase II delta 817 ENSG00000145349
11  ENSG00000167193 NA CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 1398 ENSG00000167193
12  ENSG00000134313 NA KIDINS220 kinase D-interacting substrate, 220kDa 57498 ENSG00000134313
13  ENSG00000050748 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748
14  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365
15  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
16  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
17  ENSG00000185386 NA MAPK11 mitogen-activated protein kinase 11 5600 ENSG00000185386
18  ENSG00000166484 NA MAPK7 mitogen-activated protein kinase 7 5598 ENSG00000166484
19  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
20  ENSG00000109458 NA GAB1 GRB2-associated binding protein 1 2549 ENSG00000109458
21  ENSG00000166225 NA FRS2 fibroblast growth factor receptor substrate 2 10818 ENSG00000166225
22  ENSG00000177189 NA RPS6KA3 ribosomal protein S6 kinase, 90kDa, polypeptide 3 6197 ENSG00000177189


Database:KEGG pathway       Name:Insulin signaling pathway       ID:04910
C=138; O=23; E=5.87; R=3.92; rawP=2.10e-08; adjP=3.34e-07
Index UserID Value Gene Symbol Gene Name EntrezGene Ensembl
1  ENSG00000162409 NA PRKAA2 protein kinase, AMP-activated, alpha 2 catalytic subunit 5563 ENSG00000162409
2  ENSG00000107643 NA MAPK8 mitogen-activated protein kinase 8 5599 ENSG00000107643
3  ENSG00000100485 NA SOS2 son of sevenless homolog 2 (Drosophila) 6655 ENSG00000100485
4  ENSG00000095637 NA SORBS1 sorbin and SH3 domain containing 1 10580 ENSG00000095637
5  ENSG00000157764 NA BRAF v-raf murine sarcoma viral oncogene homolog B1 673 ENSG00000157764
6  ENSG00000115904 NA SOS1 son of sevenless homolog 1 (Drosophila) 6654 ENSG00000115904
7  ENSG00000102893 NA PHKB phosphorylase kinase, beta 5257 ENSG00000102893
8  ENSG00000110395 NA CBL Cbl proto-oncogene, E3 ubiquitin protein ligase 867 ENSG00000110395
9  ENSG00000051382 NA PIK3CB phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta 5291 ENSG00000051382
10  ENSG00000002330 NA BAD BCL2-associated agonist of cell death 572 ENSG00000002330
11  ENSG00000099942 NA CRKL v-crk sarcoma virus CT10 oncogene homolog (avian)-like 1399 ENSG00000099942
12  ENSG00000196396 NA PTPN1 protein tyrosine phosphatase, non-receptor type 1 5770 ENSG00000196396
13  ENSG00000167193 NA CRK v-crk sarcoma virus CT10 oncogene homolog (avian) 1398 ENSG00000167193
14  ENSG00000050748 NA MAPK9 mitogen-activated protein kinase 9 5601 ENSG00000050748
15  ENSG00000104365 NA IKBKB inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta 3551 ENSG00000104365
16  ENSG00000180008 NA SOCS4 suppressor of cytokine signaling 4 122809 ENSG00000180008
17  ENSG00000121879 NA PIK3CA phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha 5290 ENSG00000121879
18  ENSG00000082701 NA GSK3B glycogen synthase kinase 3 beta 2932 ENSG00000082701
19  ENSG00000108443 NA RPS6KB1 ribosomal protein S6 kinase, 70kDa, polypeptide 1 6198 ENSG00000108443
20  ENSG00000109819 NA PPARGC1A peroxisome proliferator-activated receptor gamma, coactivator 1 alpha 10891 ENSG00000109819
21  ENSG00000100030 NA MAPK1 mitogen-activated protein kinase 1 5594 ENSG00000100030
22  ENSG00000114302 NA PRKAR2A protein kinase, cAMP-dependent, regulatory, type II, alpha 5576 ENSG00000114302
23  ENSG00000142875 NA PRKACB protein kinase, cAMP-dependent, catalytic, beta 5567 ENSG00000142875




WebGestalt is currently developed and maintained by Jing Wang and Bing Zhang at the Zhang Lab. Other people who have made significant contribution to the project include Dexter Duncan, Stefan Kirov, Zhiao Shi, and Jay Snoddy.

Funding credits: NIH/NIAAA (U01 AA016662, U01 AA013512); NIH/NIDA (P01 DA015027); NIH/NIMH (P50 MH078028, P50 MH096972); NIH/NCI (U24 CA159988); NIH/NIGMS (R01 GM088822).